ABSTRACT
Chinese patent medicines have the basic characteristics of great clinical value， strong scientific value and high market value. It is not only the core engine of traditional Chinese medicine （TCM） industry development but also the important content of TCM academic development， which is the great significance of the cause and industry of TCM. In this study， based on reviewing the methods and models of TCM theoretical， the innovation of TCM theory and Chinese patent medicines were hitting-point， which it is emphasized that the creation of effective formula is the concentrated embodiment of the theoretical innovation research results， and the Suhuang Zhike capsule and fengke theory， Tongxinluo capsule and collateral disease theory were taken as examples. On this basis， the ideas and strategies were put forward to realizing the theoretical innovation research of TCM with the large varieties of TCM as the carrier， that is， based on combing and analyzing the prescription rules and functional indications of the large varieties of TCM， and deepening the theoretical connotation of it. Meanwhile， not only emphasized the general theoretical understanding but also paid attention to the application of unique drugs and their compatibility. It not only satisfies the modern scientific connotation of revealing the role of TCM， but also explores unknown or possible new targets， new pathways and mechanisms by using large varieties of proprietary Chinese medicines to promote scientific discoveries and lead medical research.
ABSTRACT
The clinical value is the core factor for determining the products of Chinese patent medicines on the market. It is clear that defining the clinical positioning of Chinese patent medicines and maximizing their clinical efficacy and value are of great practical significance for each Chinese patent medicine. Precise clinical positioning not only requires systematic analysis and summarization of existing literature and clinical practice data, but also requires verification and proof from detailed experimental data, thus to provide scientific support for basic research. In this research, a three-dimensional integration strategy of " traditional Chinese medicine (TCM) theory-clinical practice-basic research" was proposed to play a vital role in clinical positioning and evaluation of Chinese patent medicines. Yixinshu capsule was taken as an example to discuss clinical positioning of Chinese patent medicines under the guidance of TCM theory. Based on the interpretation of the evolution of the pathogenesis of coronary heart disease (thoracic obstruction), combined with the core efficacy of the drug composition, the effect of Yixinshu capsule in benefiting Zongqi, calming midnd, improving blood circulation and eliminating blood stasis was identified, which was suitable for treatment for the recurrent episodes of angina pectoris, and emergency of symptoms of chronic heart failure. At the level of TCM theory, the clinical positioning of Yixinshu capsule was further defined, and the key points of in-depth research were proposed to provide reference for the mechanism research and clinical application of Yixinshu capsule. Based on the prescription and its score functions, precise analysis of clinical positioning of large varieties of TCM under the guidance of TCM theory, on the one hand will give full play to the value of TCM original knowledge and guide the basic research of Chinese patent medicines, on the other hand the research results will enrich, benefit and sublimate the TCM theory, and finally provide a critical paradigmatic for the clinical positioning of large varieties of TCM under the guidance of TCM theory.